Eczema, a condition marked by red, itchy, and inflamed skin, affects millions worldwide. While Dupixent has become a go-to treatment for those with moderate to severe eczema, many individuals are beginning to explore alternative solutions.
Whether due to concerns over potential side effects, cost, or the desire for a more holistic approach, people are seeking options that can offer relief without the need for prescription medications.
Let’s dive into some of the most popular alternative treatments for eczema and how they compare to Dupixent, helping you understand which option may be the best for your skin and lifestyle.
What Is Dupixent, and How Does It Work?
Dupixent (dupilumab) is a biologic drug that targets specific parts of the immune system to reduce inflammation and control symptoms of eczema.
It is administered via injection and is typically prescribed for individuals whose eczema is moderate to severe and who have not responded well to topical treatments.
While Dupixent can be highly effective for many, it may not be suitable for everyone. Some individuals experience side effects such as eye issues, allergic reactions, and an increased risk of infections.
Additionally, the cost of Dupixent can be a significant barrier, particularly if you don’t have insurance that covers the medication.
As a result, many individuals are seeking alternatives to Dupixent that can manage eczema symptoms without the potential downsides of prescription drugs. Let’s explore some of the most promising natural and over-the-counter treatments for eczema.
1. Topical Steroids and Non-Steroidal Creams
One of the most common treatments for eczema is topical steroids, which help reduce inflammation and itching. These creams are available in various strengths, ranging from mild over-the-counter options to more potent prescription formulations. Non-steroidal creams, such as calcineurin inhibitors, are also used to help control symptoms without the risk of thinning skin, which is a potential side effect of long-term steroid use.
While these topical treatments can be effective, they are often associated with side effects when used over extended periods, such as thinning skin, stretch marks, and increased susceptibility to infections. It is essential to use them as directed by a healthcare provider to avoid these potential risks.
2. Probiotics and Diet Adjustments
Research has shown that gut health may play a role in the development and severity of eczema. This has led some people to explore dietary changes and probiotics as a means of managing their condition. Probiotics, which are live bacteria that promote healthy gut flora, may help balance the immune system and reduce inflammation.
A diet rich in anti-inflammatory foods such as omega-3 fatty acids (found in fish, flaxseeds, and walnuts), fruits, vegetables, and whole grains can also benefit eczema sufferers.
Reducing the intake of foods known to trigger inflammation, such as refined sugars and processed foods, may also help reduce flare-ups.
These dietary changes can help manage eczema, but they tend to be most effective when combined with other topical treatments or lifestyle adjustments. I
t’s crucial to consult with a healthcare provider before making significant changes to your diet or supplement regimen to ensure you’re on the right track.
3. Light Therapy (Phototherapy)
Phototherapy, or light therapy, is a treatment that uses ultraviolet (UV) light to reduce inflammation and control eczema flare-ups. It is typically administered in a clinical setting, where controlled doses of UV light are applied to affected areas of the skin. Light therapy can be highly effective for those with moderate to severe eczema, mainly when other treatments have not been successful.
However, phototherapy does require frequent visits to a dermatologist or treatment center, which may be inconvenient for most folks. There’s also a potential risk of skin damage or an increased risk of skin cancer with prolonged UV exposure, so it’s essential to have this treatment under medical supervision.
4. Stress Management Techniques
Stress is a well-known trigger for eczema flare-ups, and managing stress effectively can help reduce the frequency and severity of symptoms. Techniques such as yoga, meditation, mindfulness, and deep breathing have all been shown to reduce stress and promote overall well-being.
For those who find that stress exacerbates their eczema, incorporating these stress-relief practices into their daily routine can provide lots of benefits, giving them the motivation to make these changes.
5. Natural Eczema Relief: A Holistic Approach
A holistic, natural approach may offer the most sustainable, long-term relief for those managing eczema. This approach emphasizes nourishing the skin, supporting overall health, and using gentle, non-toxic skincare solutions.
One of the most crucial steps in eczema care is keeping the skin well-moisturized. Dry skin can easily and quickly trigger flare-ups, making it essential to regularly moisturize with thick, emollient-rich creams or fragrance-free ointments specifically formulated for individuals with sensitive skin.
Another aspect of effective eczema management is repairing the skin’s natural barrier. The skin barrier is responsible for keeping irritants, allergens, and moisture in or out, and when it’s compromised, eczema flare-ups are more likely.
Focusing on restoring and strengthening the skin barrier can reduce the frequency of flare-ups and improve skin health in the long term.
Skincare brands like CLMD offer products designed to restore the skin’s barrier, deeply hydrate, and reduce inflammation—without relying on harsh chemicals or prescription medications. These products often include ingredients like ceramides, licorice root extract, and niacinamide, which are known for supporting the skin’s natural healing process. Together, these ingredients work to soothe irritation, lock in moisture, and help restore balance to eczema-prone skin.
By prioritizing skin barrier repair and hydration, a holistic approach to eczema care can help create lasting relief while supporting overall skin health.
Introducing CLMD’s Ultimate Eczema Kit: A Natural, Effective Solution
If you’re seeking a natural, non-prescription solution to eczema, CLMD’s Ultimate Eczema Kit may be just the relief you’re looking for.

This dermatologist-developed, 3-step skincare routine is designed to calm, protect, and maintain the balance of skin prone to eczema, offering quick and gentle relief from the discomfort of eczema flare-ups.
The Ultimate Eczema Kit includes:
- TrueLipids 1% Hydrocortisone Barrier Cream: A soothing treatment that helps calm inflammation and reduce irritation, relieving intense itching and discomfort associated with eczema.
- TrueLipids Relieve & Protect Ointment: Deeply hydrates while protecting the skin from environmental stressors, forming a barrier that restores moisture and improves texture.
- TrueLipids Ceramide+ Cream: Locks in moisture and helps restore your skin’s natural moisture barrier, maintaining hydrated and resilient skin to prevent future flare-ups.
The kit’s combination of ceramides, niacinamide, and licorice root extract works synergistically to address the root causes of eczema while soothing irritation and rebuilding the skin’s natural defenses.
Why Choose CLMD’s Ultimate Eczema Kit?
- Non-Toxic, Hypoallergenic: Free from parabens, phthalates, fragrances, and GMOs, making it safe for sensitive skin.
- Fast Relief: Provides immediate and long-lasting relief from itching, redness, and discomfort while deeply moisturizing and hydrating.
- Skin Barrier Restoration: Focuses on rebuilding the skin’s natural moisture barrier with essential lipids, ceramides, and fatty acids.
- Gentle and Effective: The products are designed to be gentle yet highly effective, delivering soothing care without harsh chemicals or prescription medications.

If you’re looking for an eczema treatment that provides both immediate relief and long-term skin health, CLMD’s Ultimate Eczema Kit offers a safe and effective alternative to Dupixent.
With a more holistic skincare approach, you can manage eczema without prescription drugs and enjoy clearer, calmer, and more comfortable skin.